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Here, thoughts and ideas concerning different aspects of the disease - including things that have been found to be wrong and their possible explanations - will be collected in order to help get a balanced big picture. The Internet is full of information and research papers on a multitude of aspects of the disease, but it is so badly managed that getting a thorough understanding of all relevant angles is practically impossible. I am trying to experiment with a mind mapping software to make some order into this mess. However, my experience on such tools is practically nonexistent so I would really appreciate any help in this.

My current tool is espresso Mind Map for Windows 8, which seems to work relatively well with the eye gaze device. The problem is, however, that what we are trying to model is a network rather than a tree, and this detail will possibly lead into troubles later on as we start looking for the connections between different aspects of the disease. If you have any suggestions, please comment e.g. using the options on the bottom of the big picture page.

Title Author Hits
On ALS and autism Written by Dave J Hits: 5158
Pathways Written by Riku Mattila Hits: 1947
On upper & lower motor neurones and the disease process Written by Dave J Hits: 2674
The Marathon Runner Phenotype Written by Dave J Hits: 4129
What causes mitochondria to dysfunction? Written by Riku Mattila Hits: 1833
The SOD1-VDAC1 hypothesis Written by Riku Mattila Hits: 2414
On spreading Written by Riku Mattila Hits: 4558
On stem cells and mitochondria Written by Dave J Hits: 6618
Outline of the data mining project Written by Riku Mattila Hits: 3898
Thoughts concerning the data mining Written by Riku Mattila Hits: 3913

Subcategories

Source Material Collections

Here I will post collections of source materials to be linked to the Big Picture Mindmap. This subcategory is created under "Solving the Puzzle" main category in order to keep it clean of the unfinished and unfriendly working documents.

Potential therapeutics & foci of intervention

Here I will collect the potential substances and processes that are recognized from the Big Picture analysis as potentially harmful for the disease (thus beneficial for the patient). The idea is to enable a more in-depth analysis of each of the components that may eventually be included in a therapeutics cocktail.

The effort is to a certain degree parallel to that done under the Supplement Strategies category, the only difference being that here the stuff originates directly from the Big Picture Mindmap.

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